Keywords

• O-Desmethylvenlafaxine
• 93413-62-8
• Factory price

Quick Details

• ProName: Factory Price O-Desmethylvenlafaxine
• CasNo: 93413-62-8
• Molecular Formula: C16H25NO2
• Appearance: White Powder
• Application: Neuronal Signaling
• DeliveryTime: 15-20 days after receive the deposit
• PackAge: Bucket/Bottled/Bags
• Port: TianJin Or QingDao
• ProductionCapacity: 500 Metric Ton/Month
• Purity: 99%
• Storage: 2-8°C
• Transportation: By express(DHL,TNT,FedEx,UPS,and other...
• LimitNum: 1 Kilogram
• Related Substances: None
• Residue on Ignition: None
• Heavy Metal: None
• Valid Period: None

Superiority

Our Advantages:

1.We have abundant professional production experience.

2.We have our own chemical factory.

3.Sample is free of charge. 

4. Reasonable Price, Excellent Quality & Attentive Service 

5. Prompt reply: we can reply your inquiry and email within 24 hours.

6.Fast Delivery: The delivery time is about 10-20 days after receiving the deposit.

7. We have a unity cooperation team

Details

Product detail: 

Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. Target: SSRIsDesvenlafaxine is a serotonin-norepinephrine reuptake inhibitor and is the active metabolite of the antidepressant venlafaxine. Similar to venlafaxine, desvenlafaxine inhibits the neuronal uptake of serotonin and norepinephrine. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter. Desvenlafaxine inhibits [3H]5-HT or [3H]NE uptake for the hSERT or hNET with IC50 of 47.3 and 531.3 nM, respectively. Desvenlafaxine rapidly penetrates the male rat brain and hypothalamus. Desvenlafaxine significantly increases extracellular NE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels using microdialysis [1]. Desvenlafaxine has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Induction of CYP3A4 is also possible with desvenlafaxine, which could impact the metabolism of drugs metabolized via this enzyme. Desvenlafaxine exhibits a linear and dose-proportional pharmacokinetic single-dose profile in a dose range from 100 to 600 mg/day. The absolute bioavailability of the oral formulation is 80.5% [2].

Company information:

ShanLong Biotechnology Co., Ltd. is a high-tech enterprise specializing in high-tech and high value-added cosmetic raw materials, pharmaceutical intermediates, chemical customization, research and development, production and sales.

The company has its own R&D center and production base,Strong technical force, complete product testing methods and quality assurance system. The company not only has a group of high-tech talents engaged in the research and development, production, and management of pharmaceutical intermediates, but also makes full use of the technological and information advantages of scientific research units in universities, and has established long-term collaboration with pharmaceutical research institutes, large domestic pharmaceutical units and enterprises around the world Relationship, our products has been exported to Europe, Japan, South Korea, North America and other countries.

 

 

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