Keywords

• Duloxetine
• 116539-59-4
• Factory Price In Stock

Quick Details

• ProName: Factory Price In Stock Duloxetine
• CasNo: 116539-59-4
• Molecular Formula: C18H19NOS
• Appearance: White Powder
• Application: Nervous system medication
• DeliveryTime: 15-20 days after receive the deposit
• PackAge: Bucket/Bottled/Bags
• Port: TianJin Or QingDao
• ProductionCapacity: 500 Metric Ton/Month
• Purity: 99%
• Storage: 2-8°C
• Transportation: By express(DHL,TNT,FedEx,UPS,and other...
• LimitNum: 1 Kilogram
• Related Substances: none
• Residue on Ignition: none
• Heavy Metal: none
• Valid Period: 2 year

Superiority

Our Advantages:

1.We have abundant professional production experience.

2.We have our own chemical factory.

3.Sample is free of charge. 

4. Reasonable Price, Excellent Quality & Attentive Service 

5. Prompt reply: we can reply your inquiry and email within 24 hours.

6.Fast Delivery: The delivery time is about 10-20 days after receiving the deposit.

7. We have a unity cooperation team

Details

Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Target: SNRIsDuloxetine inhibits the reuptake of serotonin and norepinephrine in the central nervous system. Duloxetine is also considered a less potent inhibitor of dopamine reuptake. However, duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors and can therefore be considered to be a selective reuptake inhibitor at the 5-HT and NA transporters. Duloxetine undergoes extensive metabolism, but the major circulating metabolites do not contribute significantly to the pharmacologic activity. Major depressive disorder is believed to be due in part to an increase in pro-inflammatory cytokines within the central nervous system. Antidepressants including ones with a similar mechanism of action as duloxetine, i.e. serotonin metabolism inhibition, cause a decrease in proinflammatory cytokine activity and an increase in anti-inflammatory cytokines; this mechanism may apply to duloxetine in its effect on depression but research on cytokines specific to duloxetine therapy is lacking [1]. The analgesic properties of duloxetine in the treatment of diabetic neuropathy and central pain syndromes such as fibromyalgia are believed to be due to sodium ion channel blockade [2].

Company information:

ShanLong Biotechnology Co., Ltd. is a high-tech enterprise specializing in high-tech and high value-added cosmetic raw materials, pharmaceutical intermediates, chemical customization, research and development, production and sales.

The company has its own R&D center and production base,Strong technical force, complete product testing methods and quality assurance system. The company not only has a group of high-tech talents engaged in the research and development, production, and management of pharmaceutical intermediates, but also makes full use of the technological and information advantages of scientific research units in universities, and has established long-term collaboration with pharmaceutical research institutes, large domestic pharmaceutical units and enterprises around the world Relationship, our products has been exported to Europe, Japan, South Korea, North America and other countries.

 

 

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