Keywords

• Dutasteride
• 164656-23-9
• Factory price

Quick Details

• ProName: Factory Price Dutasteride
• CasNo: 164656-23-9
• Molecular Formula: C27H30F6N2O2
• Appearance: White Powder
• Application: Prostaglandins
• DeliveryTime: 15-20 days after receive the deposit
• PackAge: Bucket/Bottled/Bags
• Port: TianJin Or QingDao
• ProductionCapacity: 500 Metric Ton/Month
• Purity: 99%
• Storage: 2-8°C
• Transportation: By express(DHL,TNT,FedEx,UPS,and other...
• LimitNum: 1 Kilogram
• Related Substances: None
• Residue on Ignition: None
• Heavy Metal: None
• Valid Period: None

Superiority

Our Advantages:

1.We have abundant professional production experience.

2.We have our own chemical factory.

3.Sample is free of charge. 

4. Reasonable Price, Excellent Quality & Attentive Service 

5. Prompt reply: we can reply your inquiry and email within 24 hours.

6.Fast Delivery: The delivery time is about 10-20 days after receiving the deposit.

7. We have a unity cooperation team

Details

Product description:

Dutasteride (GG745) is a potent inhibitor of both 5 alpha-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT.IC50 Value:Target: 5 alpha-reductasein vitro: Dutasteride inhibited (3)H-T conversion to (3)H-DHT and, as anticipated, inhibited T-induced secretion of PSA and proliferation. However the drug also inhibited DHT-induced PSA secretion and cell proliferation (IC(50) approximately 1 microM). Dutasteride competed for binding the LNCaP cell AR with an IC(50) approximately 1.5 microM. High concentrations of dutasteride (10-50 microM), but not finasteride, in steroid-free medium, resulted in enhanced cell death, possibly by apoptosis [1]. Dutasteride reduces cell viability and cell proliferation in both cell lines tested (androgen-responsive (LNCaP) and androgen-unresponsive (DU145) human prostate cancer (PCa)) [2].in vivo: GG745 has a terminal half-life of approximately 240 hr, and single doses of >10 mg decreased DHT levels significantly more than did single 5-mg doses of finasteride [3]. In placebo treated men without prostate cancer there was an 8.3% median increase in PSA at month 24 compared with -59.5% in those who received dutasteride, using doubled values to correct for dutasteride treatment [4].Toxicity: Dutasteride may affect male fertility and steroid hormone dynamics. Therefore, a 21-day reproduction study was conducted to determine the effects of dutasteride (10, 32 and 100 μg/L) on fish reproduction. Exposure to dutasteride significantly reduced fecundity of fish and affected several aspects of reproductive endocrine functions in both males and females [5].Clinical trial: Bioequivalence Study Of Dutasteride Five 0.1 mg And One 0.5 mg Soft Gelatin Capsules In Healthy Male Volunteers.

Company information:

ShanLong Biotechnology Co., Ltd. is a high-tech enterprise specializing in high-tech and high value-added cosmetic raw materials, pharmaceutical intermediates, chemical customization, research and development, production and sales.

The company has its own R&D center and production base,Strong technical force, complete product testing methods and quality assurance system. The company not only has a group of high-tech talents engaged in the research and development, production, and management of pharmaceutical intermediates, but also makes full use of the technological and information advantages of scientific research units in universities, and has established long-term collaboration with pharmaceutical research institutes, large domestic pharmaceutical units and enterprises around the world Relationship, our products has been exported to Europe, Japan, South Korea, North America and other countries.

 

 

Packing and shipping: